Houston Astros (65-49, second in the AL West) vs. Baltimore Orioles (70-43, first in the AL East)
Baltimore; Wednesday, 7:05 p.m. EDT
PITCHING PROBABLES: Astros: Cristian Javier (7-2, 4.39 ERA, 1.21 WHIP, 107 strikeouts); Orioles: Jack Flaherty (8-6, 4.28 ERA, 1.52 WHIP, 114 strikeouts)
FANDUEL SPORTSBOOK MLB LINE: Orioles -122, Astros +103; over/under is 9 runs
BOTTOM LINE: The Houston Astros bring a 1-0 advantage into the next game of the series against the Baltimore Orioles.
Baltimore is 70-43 overall and 35-22 in home games. The Orioles are 29-11 in games when they hit two or more home runs.
Houston has a 34-24 record on the road and a 65-49 record overall. The Astros have the fourth-best team ERA in the majors at 3.80.
Wednesday's game is the second meeting between these teams this season.
TOP PERFORMERS: Anthony Santander leads the Orioles with 50 extra base hits (29 doubles, a triple and 20 home runs). Gunnar Henderson is 12-for-43 with four doubles, three home runs and eight RBI over the past 10 games.
Yordan Alvarez leads the Astros with 21 home runs while slugging .599. Jose Altuve is 14-for-40 with a double, a triple, two home runs and three RBI over the last 10 games.
LAST 10 GAMES: Orioles: 7-3, .296 batting average, 3.24 ERA, outscored opponents by 27 runs
Astros: 7-3, .258 batting average, 3.68 ERA, outscored opponents by 18 runs
INJURIES: Orioles: Ramon Urias: day-to-day (heel), Austin Voth: 60-Day IL (elbow), Aaron Hicks: 10-Day IL (hamstring), Cedric Mullins: 10-Day IL (quadricep), Mychal Givens: 60-Day IL (shoulder), Keegan Akin: 15-Day IL (back), Dillon Tate: 60-Day IL (elbow), John Means: 60-Day IL (elbow)
Astros: Michael Brantley: 60-Day IL (shoulder), Lance McCullers Jr.: 60-Day IL (elbow), Luis Garcia: 60-Day IL (elbow)
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The Associated Press created this story using technology provided by Data Skrive and data from Sportradar.